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Oral Anticoagulant - Eliquis (apixaban), Pradaxa (dabigatran), Savaysa (edoxaban), Xarelto (rivaroxaban) Quantity Limit Program Summary

Policy Number: PH-91024

This program applies to Blue Partner, Commercial, GenPlus, NetResults A series, SourceRx, SourceRx-Performance, and Health Insurance Marketplace formularies.

POLICY REVIEW CYCLE                                                                                                                                                                           

Effective Date

Date of Origin 

01-01-2026            

FDA LABELED INDICATIONS AND DOSAGE

Agent(s)

FDA Indication(s)

Notes

Ref#

Eliquis®

(apixaban)

Capsule sprinkle

Tablet

Tablet for oral suspension

Reduce the risk of stroke and systemic embolism in adult patients with nonvalvular atrial fibrillation

Prophylaxis of deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE), in adult patients who have undergone hip or knee replacement surgery

Treatment of DVT and PE, and for the reduction in the risk of recurrent DVT and PE in adult patients following initial therapy

Treatment of venous thromboembolism (VTE) and reduction in the risk of recurrent VTE in pediatric patients from birth and older after at least 5 days of initial anticoagulant treatment

1

Pradaxa®

(dabigatran)

Capsule*

Reduce the risk of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation

Treatment of deep venous thrombosis (DVT) and pulmonary embolism (PE) in adult patients who have been treated with a parenteral anticoagulant for 5-10 days

Reduce the risk of recurrence of DVT and PE in adult patients who have been previously treated

Prophylaxis of DVT and PE in adult patients who have undergone hip replacement surgery

Treatment of venous thromboembolic events (VTE) in pediatric patients 8 to less than 18 years of age who have been treated with a parenteral anticoagulant for at least 5 days

Reduce the risk of recurrence of VTE in pediatric patients 8 to less than 18 years of age who have previously been treated

*generic available

2

Pradaxa®

(dabigatran)

Oral pellet

Treatment of venous thromboembolic events (VTE) in pediatric patients aged 3 months to less than 12 years of age who have been treated with a parenteral anticoagulant for at least 5 days

Reduce the risk of recurrence of VTE in pediatric patients aged 3 months to less than 12 years of age who have been previously treated 

5

Savaysa®

(edoxaban)

Tablet

Reduce the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF)

Limitation of Use for NVAF: should not be used in patients with creatinine clearance (CrCL) >95 mL/min because of increased risk of ischemic stroke compared to warfarin at the highest dose studied (60 mg) 

Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) following 5 to 10 days of initial therapy with a parenteral anticoagulant

3

Xarelto®

(rivaroxaban)

Oral suspension*

Tablet*

Reduce risk of stroke and systemic embolism in nonvalvular atrial fibrillation

Treatment of deep vein thrombosis (DVT)

Treatment of pulmonary embolism (PE)

Reduction in the risk of recurrence of DVT or PE

Prophylaxis of DVT, which may lead to PE in patients undergoing knee or hip replacement surgery

Prophylaxis of venous thromboembolism (VTE) in acutely ill medical patients

Reduction of risk of major cardiovascular events in patients with coronary artery disease (CAD)

Reduction of risk of major thrombotic vascular events in patients with peripheral artery disease (PAD), including patients after recent lower extremity revascularization due to symptomatic PAD  

Treatment of VTE and reduction in the risk of recurrent VTE in pediatric patients from birth to less than 18 years

Thromboprophylaxis in pediatric patients 2 years and older with congenital heart disease after the Fontan procedure

*generic available

4

See package insert for FDA prescribing information:  https://dailymed.nlm.nih.gov/dailymed/index.cfm

REFERENCES                                                                                                                                                                           

Number

Reference

1

Eliquis prescribing information. E.R. Squibb & Sons, LLC. April 2025.

2

Pradaxa capsules prescribing information. Boehringer Ingelheim Pharmaceuticals Inc. November 2023.

3

Savaysa prescribing information. Daiichi Sankyo Inc. October 2023.

4

Xarelto prescribing information. Janssen Pharmaceuticals, Inc. February 2023.

5

Pradaxa oral pellets prescribing information. Boehringer Ingelheim Pharmaceuticals Inc. November 2023.

POLICY AGENT SUMMARY QUANTITY LIMIT

Target Brand Agent Name(s)

Target Generic Agent Name(s)

Strength

QL Amount

Dose Form

Day Supply

Duration

Addtl QL Info

Allowed Exceptions

Targeted NDCs When Exclusions Exist

Eliquis

apixaban cap sprinkle

0.15 MG

74

Capsules

30

DAYS

Eliquis

Apixaban Tab 2.5 MG

2.5 MG

60

Tablets

30

DAYS

Eliquis

Apixaban Tab 5 MG

5 MG

74

Tablets

30

DAYS

2 tablets/day for maintenance

Eliquis

apixaban tab for oral susp

0.5 MG

5

Boxes

28

DAYS

Eliquis

apixaban tab for oral susp pack

0.5 MG

5

Boxes

28

DAYS

Eliquis

apixaban tab for oral susp pack

0.5 MG

5

Boxes

28

DAYS

Eliquis starter pack

Apixaban Tab Starter Pack

5 MG

1

Kit

180

DAYS

Pradaxa

Dabigatran Etexilate Mesylate Cap 110 MG (Etexilate Base Eq)

110 MG

120

Capsules

30

DAYS

Pradaxa

Dabigatran Etexilate Mesylate Cap 150 MG (Etexilate Base Eq)

150 MG

60

Capsules

30

DAYS

Pradaxa

Dabigatran Etexilate Mesylate Cap 75 MG (Etexilate Base Eq)

75 MG

60

Capsules

30

DAYS

Pradaxa

dabigatran etexilate mesylate pellet pack

20 MG

60

Packets

30

DAYS

Pradaxa

dabigatran etexilate mesylate pellet pack

30 MG

120

Packets

30

DAYS

Pradaxa

dabigatran etexilate mesylate pellet pack

40 MG

120

Packets

30

DAYS

Pradaxa

dabigatran etexilate mesylate pellet pack

50 MG

120

Packets

30

DAYS

Pradaxa

dabigatran etexilate mesylate pellet pack

110 MG

120

Packets

30

DAYS

Pradaxa

dabigatran etexilate mesylate pellet pack

150 MG

60

Packets

30

DAYS

Savaysa

edoxaban tosylate tab

15 MG ; 30 MG ; 60 MG

30

Tablets

30

DAYS

Xarelto

Rivaroxaban For Susp

1 MG/ML

620

mL

30

DAYS

Xarelto

Rivaroxaban Tab 10 MG

10 MG

30

Tablets

30

DAYS

Xarelto

Rivaroxaban Tab 15 MG

15 MG

60

Tablets

30

DAYS

Xarelto

Rivaroxaban Tab 2.5 MG

2.5 MG

60

Tablets

30

DAYS

Xarelto

Rivaroxaban Tab 20 MG

20 MG

30

Tablets

30

DAYS

Xarelto starter pack

Rivaroxaban Tab Starter Therapy Pack 15 MG & 20 MG

15 & 20 MG

51

Tablets

30

DAYS

CLIENT SUMMARY – QUANTITY LIMITS

Target Brand Agent Name(s)

Target Generic Agent Name(s)

Strength

Client Formulary

Eliquis

apixaban cap sprinkle

0.15 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Eliquis

Apixaban Tab 2.5 MG

2.5 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Eliquis

Apixaban Tab 5 MG

5 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Eliquis

apixaban tab for oral susp

0.5 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Eliquis

apixaban tab for oral susp pack

0.5 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Eliquis

apixaban tab for oral susp pack

0.5 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Eliquis starter pack

Apixaban Tab Starter Pack

5 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Pradaxa

Dabigatran Etexilate Mesylate Cap 110 MG (Etexilate Base Eq)

110 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Pradaxa

Dabigatran Etexilate Mesylate Cap 150 MG (Etexilate Base Eq)

150 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Pradaxa

Dabigatran Etexilate Mesylate Cap 75 MG (Etexilate Base Eq)

75 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Pradaxa

dabigatran etexilate mesylate pellet pack

40 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Pradaxa

dabigatran etexilate mesylate pellet pack

50 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Pradaxa

dabigatran etexilate mesylate pellet pack

30 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Pradaxa

dabigatran etexilate mesylate pellet pack

20 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Pradaxa

dabigatran etexilate mesylate pellet pack

150 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Pradaxa

dabigatran etexilate mesylate pellet pack

110 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Savaysa

edoxaban tosylate tab

15 MG ; 30 MG ; 60 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Xarelto

Rivaroxaban For Susp

1 MG/ML

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Xarelto

Rivaroxaban Tab 10 MG

10 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Xarelto

Rivaroxaban Tab 15 MG

15 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Xarelto

Rivaroxaban Tab 2.5 MG

2.5 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Xarelto

Rivaroxaban Tab 20 MG

20 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

Xarelto starter pack

Rivaroxaban Tab Starter Therapy Pack 15 MG & 20 MG

15 & 20 MG

Blue Partner ; Commercial ; GenPlus ; Health Insurance Marketplace ; NetResults A Series ; SourceRx ; SourceRx-Performance

QUANTITY LIMIT CLINICAL CRITERIA FOR APPROVAL

Module

Clinical Criteria for Approval

Eliquis and Savaysa

Quantity Limit for the Target Agent(s) will be approved when ONE of the following is met

  1. The requested quantity (dose) does NOT exceed the program quantity limit OR
  2. The requested quantity (dose) exceeds the program quantity limit AND ONE of the following:
    1. BOTH of the following:
      1. The requested agent does NOT have a maximum FDA labeled dose for the requested indication AND
      2. There is support for therapy with a higher dose for the requested indication OR
    2. BOTH of the following:
      1. The requested quantity (dose) does NOT exceed the maximum FDA labeled dose for the requested indication AND
      2. There is support for why the requested quantity (dose) cannot be achieved with a lower quantity of a higher strength that does NOT exceed the program quantity limit OR
    3. BOTH of the following:
      1. ​​​​​​​The requested quantity (dose) exceeds the maximum FDA labeled dose for the requested indication AND
      2. There is support for therapy with a higher dose for the requested indication​​​​​​​

Length of Approval:  12 months or the requested duration, whichever is shorter

Pradaxa

Quantity Limit for the Target Agent(s) will be approved when ONE of the following is met:

  1. The requested quantity (dose) does NOT exceed the program quantity limit OR
  2. The requested quantity (dose) exceeds the program quantity limit AND ONE of the following:
    1. BOTH of the following:
      1. The patient is an adult with a diagnosis of prophylaxis of DVT and PE who has undergone hip replacement surgery AND
      2. There is support for therapy with a higher dose for the requested indication OR
    2. BOTH of the following:
      1. The patient is an adult with ONE of the following diagnoses:
        1. DVT and PE OR
        2. Reducing the risk of recurrence of DVT and PE OR
        3. Reducing the risk of stroke and systemic embolism with nonvalvular atrial fibrillation AND
      2. BOTH of the following:
        1. The requested strength is NOT 110 mg AND
        2. ONE of the following:
          1. BOTH of the following:
            1. The requested quantity (dose) does NOT exceed the maximum FDA labeled dose for the requested indication AND
            2. There is support for why the requested quantity (dose) cannot be achieved with a lower quantity of a higher strength that does NOT exceed the program quantity limit OR
          2. BOTH of the following:
            1. The requested quantity (dose) exceeds the maximum FDA labeled dose for the requested indication AND
            2. There is support for therapy with a higher dose for the requested indication OR
    3. The patient has a diagnosis other than those previously listed AND ONE of the following:
      1. BOTH of the following:
        1. The requested agent does NOT have a maximum FDA labeled dose for the requested indication AND
        2. There is support for therapy with a higher dose for the requested indication OR
      2. BOTH of the following:
        1. The requested quantity (dose) does NOT exceed the maximum FDA labeled dose for the requested indication AND
        2. There is support for why the requested quantity (dose) cannot be achieved with a lower quantity of a higher strength that does NOT exceed the program quantity limit OR
      3. BOTH of the following:
        1. The requested quantity (dose) exceeds the maximum FDA labeled dose for the requested indication AND
        2. There is support for therapy with a higher dose for the requested indication

Length of Approval: 12 months or the requested duration, whichever is shorter

Xarelto

Quantity Limit for the Target Agent(s) will be approved when ONE of the following is met:

  1. The requested quantity (dose) does NOT exceed the program quantity limit OR
  2. The requested quantity (dose) exceeds the program quantity limit AND ONE of the following:
    1. BOTH of the following:
      1. The patient has a diagnosis of prophylaxis of DVT which may lead to PE in a patient undergoing hip or knee replacement surgery AND
      2. There is support for therapy with a higher dose for the requested indication OR
    2. BOTH of the following:
      1. The patient has ONE of the following diagnoses:
        1. DVT and PE OR
        2. Reducing the risk of stroke and systemic embolism with nonvalvular atrial fibrillation AND
      2. ONE of the following:
        1. BOTH of the following:
          1. The requested quantity (dose) does NOT exceed the maximum FDA labeled dose for the requested indication AND
          2. There is support for why the requested quantity (dose) cannot be achieved with a lower quantity of a higher strength that does NOT exceed the program quantity limit OR
        2. BOTH of the following:
          1. The requested quantity (dose) exceeds the maximum FDA labeled dose for the requested indication AND
          2. There is support for therapy with a higher dose for the requested indication OR
    3. The patient has a diagnosis other than those previously listed AND ONE of the following:
      1. BOTH of the following:
        1. The requested agent does NOT have a maximum FDA labeled dose for the requested indication AND
        2. There is support for therapy with a higher dose for the requested indication OR
      2. BOTH of the following:
        1. The requested quantity (dose) does NOT exceed the maximum FDA labeled dose for the requested indication AND
        2. There is support for why the requested quantity (dose) cannot be achieved with a lower quantity of a higher strength that does NOT exceed the program quantity limit OR
      3. BOTH of the following:
        1. The requested quantity (dose) exceeds the maximum FDA labeled dose for the requested indication AND
        2. There is support for therapy with a higher dose for the requested indication

Length of Approval: 12 months or the requested duration, whichever is shorter

This pharmacy policy is not an authorization, certification, explanation of benefits or a contract. Eligibility and benefits are determined on a case-by-case basis according to the terms of the member’s plan in effect as of the date services are rendered. All pharmacy policies are based on (i) information in FDA approved package inserts (and black box warning, alerts, or other information disseminated by the FDA as applicable); (ii) research of current medical and pharmacy literature; and/or (iii) review of common medical practices in the treatment and diagnosis of disease as of the date hereof. Physicians and other providers are solely responsible for all aspects of medical care and treatment, including the type, quality, and levels of care and treatment.

The purpose of Blue Cross and Blue Shield of Alabama’s pharmacy policies are to provide a guide to coverage. Pharmacy policies are not intended to dictate to physicians how to practice medicine. Physicians should exercise their medical judgment in providing the care they feel is most appropriate for their patients.

Neither this policy, nor the successful adjudication of a pharmacy claim, is guarantee of payment.

 

Commercial _ PS _ Oral Anticoagulant_QL _ProgSum_ 01-01-2026