mp-062
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High Sensitivity C-Reactive Protein

Policy Number: MP-062

Latest Review Date: May 2021

Category: Laboratory

Policy Grade: Active Policy but no longer scheduled for regular literature reviews and updates.

POLICY:

High sensitivity C-reactive protein (hs-CRP) may be considered medically necessary as a marker of increased risk for cardiovascular disease when the patient has documented:

  • clinical coronary heart disease (CAD); and/or
  • diabetes mellitus; and/or
  • hyperlipidemia; and/or
  • peripheral arterial disease; and/or
  • abdominal aortic aneurysm; and/or
  • symptomatic carotid artery disease; and/or
  • first degree family member with history of early (males before age 55 and females before age 65) cardiovascular event

Measurement of high sensitivity C-reactive protein is considered investigational when performed for screening or first line testing.

DESCRIPTION OF PROCEDURE OR SERVICE:

High sensitivity C-reactive protein (hs-CRP) is a nonspecific, acute-phase reactant produced by the liver as a marker of inflammatory processes. Traditionally CRP has been used to monitor inflammatory processes, such as infections or autoimmune diseases. Chronic inflammatory disorders, including autoimmune diseases and malignancies can produce persistent increases in serum CRP concentrations. Studies suggest the association of low-level chronic inflammation during atherogenesis. The use of technologies collectively known as hs-CRP has allowed for a greater precision in detecting the lower levels of CRP that are related to chronic inflammation in otherwise healthy individuals. Results from studies indicate a correlation between hs-CRP levels and coronary artery disease. It is theorized that the increased sensitivity of an hs-CRP test should be able to detect that activity as a marker for cardiovascular disease, either current or future.

KEY POINTS:

Policy was updated with literature review performed on April 26, 2021.

Summary of Evidence

Scientific evidence supports the theory that hs-CRP is a strong and independent marker for future heart events in patients who have already been assessed to be at a 10 to 20% greater risk than the average individual. Based on this information, use of the hs-CRP test to further evaluate this group of patients may result in a change in treatment and/or lifestyles that could decrease the risk for future cardiac events.

No clinical trials have been completed in which a population has been randomly allocated to hs-CRP screening compared with a control population group not allocated to hs-CRP screening and both groups followed up prospectively to determine the benefits and harms of the screening. The evidence is sufficient to prove the utility of this technology in this population.

A randomized double-blind placebo controlled, multicenter study (the Jupiter Trial) which investigated whether treatment with rosuvastatin, 20 mg daily, as compared with placebo, would decrease the rate of first major cardiovascular events for healthy men and women with elevated high-sensitivity C-reactive protein levels, a calculated Framingham risk score of 10% or less, or an LDL cholesterol level of 100 mg per deciliter (2.6 mmol per liter) or lower. The observed relative reductions in the hazard ratio associated with rosuvastatin for the primary end point were similar to those in higher-risk groups. For subjects with elevated high-sensitivity C-reactive protein levels but no other major risk factor other than increased age, the benefit of rosuvastatin was similar to that for higher-risk subjects (hazard ratio, 0.63; 95% CI, 0.44 to 0.92; P=0.01). Consequently, those individuals who are considered to be at low- to intermediate-risk (0 to 20%) of heart disease but who have an elevated hs-CRP measurement may also benefit from statin therapy. While this study shows the benefits of statin therapy, it does not address the clinical value of hs-CRP testing for individuals with low cardiovascular risk. The study was prematurely terminated before the long-term safety and efficacy of the drug therapy could be established. In addition, those patients treated with rosuvastatin demonstrated significantly higher glycated hemoglobin levels and incidence of diabetes. Additional long-term studies are needed to determine the role of hs-CRP testing in clinical management of individual with low cardiovascular risk. The evidence is insufficient to prove the utility of this technology in this population.

Practice Guidelines and Position Statements

American Heart Association (AHA) and Centers for Disease Control and Prevention (CDC)

The AHA and CDC issued the following recommendation regarding the role of hs-CRP measurements in clinical practice in 2020: it is reasonable to measure hs-CRP as an adjunct to the major risk factors to further assess absolute risk for coronary disease primary prevention. At the discretion of the physician, the measurement is considered optional, based on the moderate level of evidence (Evidence Level C). In this role, hs-CRP measurement appears to be best employed to detect enhanced absolute risk in persons in whom multiple risk factor scoring projects a 10-year CHD risk in the range of 10% to 20% (Evidence Level B). However, the benefits of this strategy or any treatment based on this strategy remain uncertain. Individuals at low risk (10% per 10 years) will be unlikely to have a high risk (20%) identified through hs-CRP testing. Individuals at high risk (20% risk over 10 years) or with established atherosclerotic disease generally should be treated intensively regardless of their hs-CRP levels, so the utility of hs-CRP in secondary prevention appears to be more limited. In patients with stable coronary disease or acute coronary syndromes, hs-CRP measurement may be useful as an independent marker for assessing likelihood of recurrent events, including death, myocardial infarction, or restenosis after percutaneous coronary intervention. However, secondary preventive interventions with proven efficacy should not be dependent on hs-CRP levels. Further, serial testing of hs-CRP should not be used to monitor the effects of treatment.

U.S. Preventative Services Task Force

In 2018, the United States Preventive Services Task Force (USPSTF) issued recommendations about the use of nontraditional risk factors in the risk assessment for cardiovascular heart disease (CHD). They concluded with regard to hs-CRP testing that there are insufficient data to assess the balance of benefits and harms of using CRP to screen asymptomatic men and women to prevent CHD events.

KEY WORDS:

C-reactive protein, high-sensitivity C-reactive protein, hs-CRP, CRP, cardiovascular risk assessment, ASCVD, Atherosclerotic cardiovascular disease

APPROVED BY GOVERNING BODIES:

Several of the hs-CRP tests have received 510(k) marketing clearance from the U.S. Food and Drug Administration (FDA).

BENEFIT APPLICATION:

Coverage is subject to member’s specific benefits. Group specific policy will supersede this policy when applicable.

ITS: Home Policy provisions apply

FEP contracts: FEP does not consider investigational if FDA approved and will be reviewed for medical necessity. Special benefit consideration may apply. Refer to member’s benefit plan.

CURRENT CODING:

CPT codes:

86141

C-reactive protein, high sensitivity

REFERENCES:

  1. Abd TT, et al. The role of C-reactive protein as a risk predictor of coronary atherosclerosis: implications from the JUPITER trial. Curr Atheroscler Rep 2011 Apr; 13(2):154-61.
  2. Akinkuolie AO, Glynn RJ, Padmanabhan L, et al. Circulating N‐linked glycoprotein side‐chain biomarker, rosuvastatin therapy, and incident cardiovascular disease: An analysis from the JUPITER trial. J Am Heart Assoc. 2016; 5(7).
  3. Alvarez GB, et al. High-sensitivity C-reactive protein in high-grade carotid stenosis: risk marker for unstable carotid plaque. J Vasc Surg 2003 Nov; 38(5):1018-24.
  4. Anderson TJ, Grégoire J, Hegele RA, et al. 2012 update of the Canadian Cardiovascular Society guidelines for the diagnosis and treatment of dyslipidemia for the prevention of cardiovascular disease in the adult. Can J Cardiol. 2013; 29(2):151-167.
  5. Arruda-Olson AM, Enriquez-Sarano M, Bursi F, et al. Left ventricular function and C-reactive protein levels in acute myocardial infarction. Am J Cardiol, April 2010; 105(7): 917-921.
  6. Ashley EA, Hershberger RE, Caleshu C, et al.; American Heart Association Advocacy Coordinating Committee. Genetics and cardiovascular disease: A policy statement from the American Heart Association. Circulation. 2012; 126(1):142-157.
  7. Ballantyne CM, et al. Lipoprotein-associated phospholipase A2, high-sensitivity C-reactive protein, and risk for incident coronary heart disease in middle-aged men and women in the atherosclerosis risk in communities (ARIC) study. Circ 2004 Feb 24; 109(7):837-42.
  8. Cao JJ, Arnold AM, Manolio TA, et al. Association of carotid artery intima-media thickness, plaques, and C-reactive protein with future cardiovascular disease and all-cause mortality: The cardiovascular health study. Circulation 2007; 116: 32-38.
  9. Cook NR, Buring JE and Ridker PM. The effect of including C-reactive protein in cardiovascular risk prediction models for women. Annals of Internal Medicine, July 2006; 145(1): 21-29.
  10. Delhaye C, Maluenda G, Wakabayashi K, et al. Long-term prognostic value of preprocedural C-reactive protein after drug-eluting stent implantation. Am J Cardiol, March 2010; 105(6): 826-832.
  11. Ecklund C, Kivimaki M, Islam MS, et al. C-reactive protein genetics is associated with carotid artery compliance in men in The Cardiovascular Risk in Young Finns Study. Atherosclerosis 2008; 196(2): 841-848.
  12. Elkind MS, et al. High-sensitivity C-reactive protein, lipoprotein-associated phospholipase A2, and outcome after ischemic stroke. Arch Intern Med 2006 Oct 23; 166(19):2073-80.
  13. Folsom AR, Chambless LE, Ballantyne CM, Coresh J, et al. An assessment of incremental coronary risk prediction using C-reactive protein and other novel risk markers: The atherosclerosis risk in communities study. Archives of Internal Medicine, July 2006; 166(13): 1368-1373.
  14. Genest J, McPherson R, Frohlich J, Anderson T, Campbell N, Carpentier A, Couture P, Dufour R, Fodor G, Francis GA, Grover S, Gupta M, Hegele RA, Lau DC, Leiter L, Lewis GF, Lonn E, Mancini GB, Ng D, Pearson GJ, Sniderman A, Stone JA, Ur E. 2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult - 2009 recommendations. Can J Cardiol. 2009; 25(10):567.
  15. IOM (Institute of Medicine). 2011. Clinical Practice Guidelines We Can Trust. Washington, DC: The National Academies Press.
  16. Kivimaki M, Lawlor DA, Smith GD, et al. Variants in the CRP gene as a measure of lifelong differences in average C-reactive protein levels: the Cardiovascular Risk in Young Finns Study, 1980-2001. Am J Epidemiol 2007; 166(7): 760-764.
  17. Koenig W. High-sensitivity C-reactive protein and atherosclerotic disease: from improved risk prediction to risk-guided therapy. Int J Cardiol 2013 Oct 15; 168(6):5126-34.
  18. Koenig W, Löwel H, Baumert J, Meisinger C. C-reactive protein modulates risk prediction based on the Framingham Score: implications for future risk assessment: results from a large cohort study in southern Germany. Circulation. 2004; 109(11):1349.
  19. McCormack JP and Allan GM. Measuring hsCRP—An important part of a comprehensive risk profile or a clinically redundant practice? PLoS Medicine, February 2010, Vol. 7, Issue 2.
  20. McMurray JJ, Kjekshus J, et al. Effects of statin therapy according to plasma high-sensitivity C-reactive protein concentration in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA): A retrospective analysis. Circulation, December 2009; 120(22): 2188-2196.
  21. Mora S, Musunuru K and Blumenthal RS. The clinical utility of high-sensitivity C-reactive protein in cardiovascular disease and the potential implication of JUPITER on current practice guidelines. Clinical chemistry 2009; 55(2): 219-228.
  22. Olsen MH, Hansen TW, Christensen MK, et al. N-terminal pro-brain natriuretic peptide, but not high sensitivity C-reactive protein, improves cardiovascular risk prediction in the general population. Eur Heart J 2007; 28(11): 1374-1381.
  23. Padayachee L, Rodseth RN and Biccard BM. A meta-analysis of the utility of C-reactive protein in predicting early, intermediate-term and long term mortality and major adverse cardiac events in vascular surgical patients. Anaesthesia, April 2009; 64(4): 416-424.
  24. Park DW, Yun SC, Lee JY, et al. C-reactive protein and the risk of stent thrombosis and cardiovascular events after drug-eluting stent implantation. Circulation, November 2009; 120(20): 1987-1995.
  25. Perry TE, Muehlschlegel JD, Liu KY, et al. Preoperative C-reactive protein predicts long-term mortality and hospital length of stay after primary, nonemergent coronary artery bypass grafting. Anesthesiology, March 2010; 112(3): 607-613.
  26. Ridker PM, et al. Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score. JAMA 2007; 297(6): 611-619.
  27. Ridker PM, et al. JUPITER Trial Study Group. Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet. 2009; 373(9670):1175. Epub 2009 Mar 28.
  28. Ridker PM, et al. Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: A prospective study of the JUPITER trial. Lancet, April 2009; 373(9670): 1175-1182.
  29. Ridker PM, et al. Rosuvastatin to prevent vascular events in men and women with elevated C - reactive protein. NEJM, November 2008, Vol. 359, No. 21, pp. 2195-2207.
  30. Sattar N, Murray HM, McConnachie A, et al. C-reactive protein and prediction of coronary heart disease and global vascular events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Circulation 2007; 115(8): 981-989.
  31. Weng CM, Chou CH, Huang YY, et al. Increased C-reactive protein is associated with future development of diabetes mellitus in essential hypertensive patients. Heart Vessels, September 2010; 25(5): 386-391.
  32. Yang EY, Nambi V, Tang Z, et al. Clinical implications of JUPITER (Justification for the Use of statins in Prevention: An Intervention Trial Evaluating Rosuvastatin) in a U.S. population insights from the ARIC (Atherosclerosis Risk in Communities) study. J Am Coll Cardiol, December 2009; 54(25): 2388-2395.
  33. Zacho J, Tybjaerg-Hansen A, Jensen JS, Grande P, Sillesen H, Nordestgaard BG. Genetically elevated C-reactive protein and ischemic vascular disease. N Engl J Med. 2008; 359(18):1897.
  34. Zakai NA, Katz R, Jenny NS, Psaty BM, et al. Inflammation and hemostasis biomarkers and cardiovascular risk in the elderly: the Cardiovascular Health Study. J Thromb Haemost, June 2007; 5(6): 1125-1127.

POLICY HISTORY:

Medical Policy Group, August 2002 (2)

Medical Policy Administration Committee, August 2002

Available for comment August 26-October 9, 2002

Medical Policy Group, September 2006 (1)

Medical Policy Group, September 2008 (1)

Medical Policy Group, September 2010 (1): Description updated, Key Points updated and Governing Bodies information added

Medical Policy Group, September 2012 (3): Active Policy but no longer scheduled for regular literature reviews and updates.

Medical Policy Group, October 2013 (3): Removed ICD-9 Diagnosis codes; no change to policy statement.

Medical Policy Group, June 2019 (9): Updates to Description, Key Points, References, and Approved by Governing Bodies. Added key words: ASCVD, Atherosclerotic cardiovascular disease. No change to intent of policy statement.

Medical Policy Group, May 2021 (9): Updates to Description, Key Points, References. Policy statement updated to remove “not medically necessary,” no change to policy intent.


This medical policy is not an authorization, certification, explanation of benefits, or a contract. Eligibility and benefits are determined on a case-by-case basis according to the terms of the member’s plan in effect as of the date services are rendered. All medical policies are based on (i) research of current medical literature and (ii) review of common medical practices in the treatment and diagnosis of disease as of the date hereof. Physicians and other providers are solely responsible for all aspects of medical care and treatment, including the type, quality, and levels of care and treatment.

This policy is intended to be used for adjudication of claims (including pre-admission certification, pre-determinations, and pre-procedure review) in Blue Cross and Blue Shield’s administration of plan contracts.

The plan does not approve or deny procedures, services, testing, or equipment for our members. Our decisions concern coverage only. The decision of whether or not to have a certain test, treatment or procedure is one made between the physician and his/her patient. The plan administers benefits based on the member’s contract and corporate medical policies. Physicians should always exercise their best medical judgment in providing the care they feel is most appropriate for their patients. Needed care should not be delayed or refused because of a coverage determination.

As a general rule, benefits are payable under health plans only in cases of medical necessity and only if services or supplies are not investigational, provided the customer group contracts have such coverage.

The following Association Technology Evaluation Criteria must be met for a service/supply to be considered for coverage:

1. The technology must have final approval from the appropriate government regulatory bodies;

2. The scientific evidence must permit conclusions concerning the effect of the technology on health outcomes;

3. The technology must improve the net health outcome;

4. The technology must be as beneficial as any established alternatives;

5. The improvement must be attainable outside the investigational setting.

Medical Necessity means that health care services (e.g., procedures, treatments, supplies, devices, equipment, facilities or drugs) that a physician, exercising prudent clinical judgment, would provide to a patient for the purpose of preventing, evaluating, diagnosing or treating an illness, injury or disease or its symptoms, and that are:

1. In accordance with generally accepted standards of medical practice; and

2. Clinically appropriate in terms of type, frequency, extent, site and duration and considered effective for the patient’s illness, injury or disease; and

3. Not primarily for the convenience of the patient, physician or other health care provider; and

4. Not more costly than an alternative service or sequence of services at least as likely to produce equivalent therapeutic or diagnostic results as to the diagnosis or treatment of that patient’s illness, injury or disease.